Search on: CASPASE 8 
Descriptors Found: 1
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Descriptor English:   Caspase 8 
Descriptor Spanish:   Caspasa 8 
Descriptor Portuguese:   Caspase 8 
Tree Number:   D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.644.360.075.405.550.800
D12.776.476.075.405.550.800
Definition English:   A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. 
Entry Combination - descr/qualif English:   Caspase 8/deficiency use Alstrom Syndrome
 
See Related English:   Autoimmune Lymphoproliferative Syndrome
 
History Note English:   2007(2000) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   52227 
Unique Identifier:   D053181 

Occurrence in VHL: 		 

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